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inhibitor of egfr kinase and brd4  (MultiTarget Pharmaceuticals)

 
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    Structured Review

    MultiTarget Pharmaceuticals inhibitor of egfr kinase and brd4
    High-throughput computational screening pipeline to identify dual inhibitors of EGFR kinase and <t>BRD4(1).</t>
    Inhibitor Of Egfr Kinase And Brd4, supplied by MultiTarget Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/inhibitor of egfr kinase and brd4/product/MultiTarget Pharmaceuticals
    Average 90 stars, based on 1 article reviews
    inhibitor of egfr kinase and brd4 - by Bioz Stars, 2026-02
    90/100 stars

    Images

    1) Product Images from "Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4"

    Article Title: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

    Journal: Scientific Reports

    doi: 10.1038/srep16924

    High-throughput computational screening pipeline to identify dual inhibitors of EGFR kinase and BRD4(1).
    Figure Legend Snippet: High-throughput computational screening pipeline to identify dual inhibitors of EGFR kinase and BRD4(1).

    Techniques Used: High Throughput Screening Assay

    Evaluation and characterization of the BRD4 docking data fusion model.
    Figure Legend Snippet: Evaluation and characterization of the BRD4 docking data fusion model.

    Techniques Used:

    Docking scores versus reported BRD4 pActivities (pIC 50 /pK d /pK i ) and Pearson correlation results of representative BRD4 inhibitors by chemotypes.
    Figure Legend Snippet: Docking scores versus reported BRD4 pActivities (pIC 50 /pK d /pK i ) and Pearson correlation results of representative BRD4 inhibitors by chemotypes.

    Techniques Used:

    Circles represent purchased compounds tested in the BRD4(1) assay, categorized by their activity against BRD4 and EGFR. Only compounds that were confirmed active against BRD4 were further tested for activity against EGFR; any of the black circles therefore could also be EGFR actives.
    Figure Legend Snippet: Circles represent purchased compounds tested in the BRD4(1) assay, categorized by their activity against BRD4 and EGFR. Only compounds that were confirmed active against BRD4 were further tested for activity against EGFR; any of the black circles therefore could also be EGFR actives.

    Techniques Used: Activity Assay

    ( A ) Average concentration-response profile of compound 2870 and known BRD4 inhibitor I-BET151 using the BRD4(1) biochemical alpha screen assay (n = 3). Emission data was normalized using DMSO and is reported as % response. Average IC 50 of 2870 was found to be 9.02 μ M against BRD4(1). ( B ) The EGFR kinase radioisotope filter binding assay was performed at a substrate concentration of 10 μ M against 2870 and Staurosporine (n = 3). Average IC 50 of 2870 was found to be 0.044 μ M against EGFR kinase.
    Figure Legend Snippet: ( A ) Average concentration-response profile of compound 2870 and known BRD4 inhibitor I-BET151 using the BRD4(1) biochemical alpha screen assay (n = 3). Emission data was normalized using DMSO and is reported as % response. Average IC 50 of 2870 was found to be 9.02 μ M against BRD4(1). ( B ) The EGFR kinase radioisotope filter binding assay was performed at a substrate concentration of 10 μ M against 2870 and Staurosporine (n = 3). Average IC 50 of 2870 was found to be 0.044 μ M against EGFR kinase.

    Techniques Used: Concentration Assay, Filter-binding Assay

    Activity from the alphascreen assay against BRD4(1) and closest topological similarity to known BRD4(1) binders is also shown. Five other compounds comprising the same sulfonamide scaffold as 8302 were also confirmed actives but are not displayed.
    Figure Legend Snippet: Activity from the alphascreen assay against BRD4(1) and closest topological similarity to known BRD4(1) binders is also shown. Five other compounds comprising the same sulfonamide scaffold as 8302 were also confirmed actives but are not displayed.

    Techniques Used: Activity Assay, Amplified Luminescent Proximity Homogenous Assay

    Binding affinity of 2870.
    Figure Legend Snippet: Binding affinity of 2870.

    Techniques Used: Binding Assay



    Similar Products

    inhibitor of egfr kinase and brd4  (MultiTarget Pharmaceuticals)
    90
    MultiTarget Pharmaceuticals inhibitor of egfr kinase and brd4
    High-throughput computational screening pipeline to identify dual inhibitors of EGFR kinase and <t>BRD4(1).</t>
    Inhibitor Of Egfr Kinase And Brd4, supplied by MultiTarget Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/inhibitor of egfr kinase and brd4/product/MultiTarget Pharmaceuticals
    Average 90 stars, based on 1 article reviews
    inhibitor of egfr kinase and brd4 - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    High-throughput computational screening pipeline to identify dual inhibitors of EGFR kinase and BRD4(1).

    Journal: Scientific Reports

    Article Title: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

    doi: 10.1038/srep16924

    Figure Lengend Snippet: High-throughput computational screening pipeline to identify dual inhibitors of EGFR kinase and BRD4(1).

    Article Snippet: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.

    Techniques: High Throughput Screening Assay

    Evaluation and characterization of the BRD4 docking data fusion model.

    Journal: Scientific Reports

    Article Title: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

    doi: 10.1038/srep16924

    Figure Lengend Snippet: Evaluation and characterization of the BRD4 docking data fusion model.

    Article Snippet: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.

    Techniques:

    Docking scores versus reported BRD4 pActivities (pIC 50 /pK d /pK i ) and Pearson correlation results of representative BRD4 inhibitors by chemotypes.

    Journal: Scientific Reports

    Article Title: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

    doi: 10.1038/srep16924

    Figure Lengend Snippet: Docking scores versus reported BRD4 pActivities (pIC 50 /pK d /pK i ) and Pearson correlation results of representative BRD4 inhibitors by chemotypes.

    Article Snippet: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.

    Techniques:

    Circles represent purchased compounds tested in the BRD4(1) assay, categorized by their activity against BRD4 and EGFR. Only compounds that were confirmed active against BRD4 were further tested for activity against EGFR; any of the black circles therefore could also be EGFR actives.

    Journal: Scientific Reports

    Article Title: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

    doi: 10.1038/srep16924

    Figure Lengend Snippet: Circles represent purchased compounds tested in the BRD4(1) assay, categorized by their activity against BRD4 and EGFR. Only compounds that were confirmed active against BRD4 were further tested for activity against EGFR; any of the black circles therefore could also be EGFR actives.

    Article Snippet: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.

    Techniques: Activity Assay

    ( A ) Average concentration-response profile of compound 2870 and known BRD4 inhibitor I-BET151 using the BRD4(1) biochemical alpha screen assay (n = 3). Emission data was normalized using DMSO and is reported as % response. Average IC 50 of 2870 was found to be 9.02 μ M against BRD4(1). ( B ) The EGFR kinase radioisotope filter binding assay was performed at a substrate concentration of 10 μ M against 2870 and Staurosporine (n = 3). Average IC 50 of 2870 was found to be 0.044 μ M against EGFR kinase.

    Journal: Scientific Reports

    Article Title: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

    doi: 10.1038/srep16924

    Figure Lengend Snippet: ( A ) Average concentration-response profile of compound 2870 and known BRD4 inhibitor I-BET151 using the BRD4(1) biochemical alpha screen assay (n = 3). Emission data was normalized using DMSO and is reported as % response. Average IC 50 of 2870 was found to be 9.02 μ M against BRD4(1). ( B ) The EGFR kinase radioisotope filter binding assay was performed at a substrate concentration of 10 μ M against 2870 and Staurosporine (n = 3). Average IC 50 of 2870 was found to be 0.044 μ M against EGFR kinase.

    Article Snippet: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.

    Techniques: Concentration Assay, Filter-binding Assay

    Activity from the alphascreen assay against BRD4(1) and closest topological similarity to known BRD4(1) binders is also shown. Five other compounds comprising the same sulfonamide scaffold as 8302 were also confirmed actives but are not displayed.

    Journal: Scientific Reports

    Article Title: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

    doi: 10.1038/srep16924

    Figure Lengend Snippet: Activity from the alphascreen assay against BRD4(1) and closest topological similarity to known BRD4(1) binders is also shown. Five other compounds comprising the same sulfonamide scaffold as 8302 were also confirmed actives but are not displayed.

    Article Snippet: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.

    Techniques: Activity Assay, Amplified Luminescent Proximity Homogenous Assay

    Binding affinity of 2870.

    Journal: Scientific Reports

    Article Title: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

    doi: 10.1038/srep16924

    Figure Lengend Snippet: Binding affinity of 2870.

    Article Snippet: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.

    Techniques: Binding Assay